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KMID : 0880220140520040340
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Journal of Microbiology
2014 Volume.52 No. 4 p.340 ~ p.344
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Antiviral Effect of Flavonol Glycosides Isolated from the Leaf of Zanthoxylum piperitum on Influenza Virus
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Ha Song-Yi
Youn Ha-Na
Chang-Seon Song
Kang Se-Chan
Bae Jong-Jin
Kim Hee-Tae
Lee Kwang-Min
Eom Tae-Hoon
Kim In-Su
Kwak Jong-Hwan
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Abstract
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The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-β-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. The anti-influenza viral activity of isolates was evaluated using a plaque reduction assay against influenza A/NWS/33 (H1N1) virus. The compounds also were subjected to neuraminidase inhibition assay in influenza A/NWS/33 virus. Compounds 1-3 exhibited antiviral activity against an influenza A virus in vitro, and inhibited the neuraminidase activity at relatively high concentrations.
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KEYWORD
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Zanthoxylum piperitum, Rutaceae, flavonol glycoside, anti-influenza activity, neuraminidase inhibitor
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